Key result
Intravenous digital subtraction arteriography concurred with surgical findings in 83.3% of carotid lesions, yielding an overall sensitivity of 93.7% for affecting clinical management.
Why the study?
Does intravenous DSA accurately detect extracranial carotid lesions compared to surgical findings and other imaging modalities in patients with suspected ischemic cerebrovascular disease?
Observational (n=306)
Does intravenous DSA accurately detect extracranial carotid lesions compared to surgical findings and other imaging modalities in patients with suspected ischemic cerebrovascular disease?
Intravenous DSA is a highly sensitive imaging modality for detecting surgical extracranial carotid lesions, performing comparably to conventional arteriography and better than sonography alone.
May support IV DSA for carotid lesions; leaves open need for prospective validation before practice change.
Intravenous digital subtraction arteriography (DSA) was performed in 306 patients with suspected ischemic cerebrovascular disease. Forty-eight carotid endarterectomies were performed in 43 of these patients. The percentage stenosis as determined on the intravenous DSA examination concurred (+/- 10%) with the surgical findings in 83.3%. There were 12.5% undercalls (false-negatives) and 4.3% overcalls (false-positives). Of the false-negative and false-positive examinations only three would have affected the clinical management of the patient, yielding an overall sensitivity of 93.7%. Nine surgical lesions had both intravenous DSA and conventional arteriography. Intravenous DSA was correct in six and arteriography in seven of these lesions. There were four surgically confirmed ulcerations. Two were evaluated by intravenous DSA alone. Two had intravenous DSA and arteriography. The latter showed both ulcers; the former, only one. Thirty-seven surgical lesions had both intravenous DSA and high-resolution real-time sonographic imaging. Sonography agreed in 67.5% and intravenous DSA in 83.7% of these lesions. When an abnormal supraorbital Doppler or an abnormal oculopneumoplethysmography/Gee examination is added to the sonographic examination, an overall sensitivity of 93% was obtained in detecting a surgical lesion (stenosis greater than 50%).
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Sheldon et al. (1984) conducted an observational in suspected ischemic cerebrovascular disease (n=306). Intravenous digital subtraction arteriography (DSA) vs. Surgical findings, conventional arteriography, and sonography was evaluated on Concurrence of percentage stenosis with surgical findings (+/- 10%). Intravenous digital subtraction arteriography concurred with surgical findings in 83.3% of carotid lesions, yielding an overall sensitivity of 93.7% for affecting clinical management.
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