Key result
18 F-FDG PET with propranolol premedication successfully characterized a benign lipomatous hypertrophy of the interatrial septum by extinguishing FDG uptake, avoiding an invasive procedure.
Why the study?
Lipomatous hypertrophy of the interatrial septum contains variable brown adipose tissue causing 18 F-FDG PET uptake, complicating distinction from malignancy when CT and cardiac MR are inconclusive.
Does beta-blocker premedication reduce 18F-FDG uptake in lipomatous hypertrophy of the interatrial septum to differentiate it from malignancy?
Case Report (n=1)
Does beta-blocker premedication reduce 18F-FDG uptake in lipomatous hypertrophy of the interatrial septum to differentiate it from malignancy?
Propranolol premedication before 18F-FDG PET can suppress brown adipose tissue uptake in lipomatous hypertrophy of the interatrial septum, helping to differentiate it from malignancy and avoid invasive procedures.
FDG uptake in interatrial lesions may reflect benign LHIS with brown fat; case report leaves open PET specificity for cardiac masses.
Lipomatous hypertrophy of the interatrial septum is a rare lesion of the heart. CT and cardiac MR are often sufficient to determine the benign lipomatous nature of the tumor and can avoid the need for histological confirmation. Lipomatous hypertrophy of the interatrial septum contains variable amounts of brown adipose tissue, resulting in different degrees of 18 F-FDG uptake in PET. We report the case of a patient with an interatrial lesion suspected of malignancy, discovered on CT and failing cardiac MR, with initial 18 F-FDG uptake. Final characterization was made thanks to 18 F-FDG PET with β-blocker premedication, avoiding an invasive procedure.
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Callaud et al. (2023) conducted a case report in Lipomatous hypertrophy of the interatrial septum (n=1). 18 F-FDG PET with propranolol premedication was evaluated on Final characterization of the lesion / extinction of FDG uptake. 18 F-FDG PET with propranolol premedication successfully characterized a benign lipomatous hypertrophy of the interatrial septum by extinguishing FDG uptake, avoiding an invasive procedure.
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