The EPIC-26 domain scores after radical prostatectomy are associated with the personality trait of neuroticism
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Key result
High neuroticism was significantly associated with lower mean scores across all EPIC-26 domains, indicating increased self-reported adverse effects after robot-assisted radical prostatectomy.
Why the study?
Neuroticism represents vulnerability for mental distress to somatic health problems, but few studies have evaluated neuroticism in prostate cancer patients.
Does high neuroticism associate with increased self-reported adverse effects after robot-assisted radical prostatectomy in prostate cancer patients?
Population
524 men who had RALP at Oslo University Hospital, Radiumhospitalet
Comparison
High vs low levels of neuroticism
Design
Cross-sectional survey study
Authors
Discussion
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Member takes
Implication
Neuroticism may correlate with higher post-RALP adverse effect reports; leaves open screening or intervention value in prostate cancer.
Study Design
Type
Cross-Sectional (n=524)
Multicenter
No
Structured PICO
Does high neuroticism associate with increased self-reported adverse effects after robot-assisted radical prostatectomy in prostate cancer patients?
P
Population
524 men who underwent robot-assisted radical prostatectomy for prostate cancer, free of treatment failure, assessed at a mean of 3.3 years post-surgery.
E
Exposure
High neuroticism (self-rated on Eysenck Personality Questionnaire, score 3-6)
C
Comparator
Low neuroticism (self-rated on Eysenck Personality Questionnaire, score 0-2)
O
Outcome
Self-reported adverse effects measured by EPIC-26 domain scores (urinary, bowel, sexual, and hormonal domains)patient reported
Main Result
p-value: p=<0.001
High neuroticism is significantly associated with increased self-reported adverse effects after radical prostatectomy, suggesting a need for pre-operative screening and tailored counseling.
Limitations
- Cross-sectional design limits causal inference.
- Data were collected nearly 10 years ago from the first cohort of men treated with RALP at the hospital, potentially reflecting surgical learning curve effects.
- Small number of patients with high neuroticism in the recurrence sensitivity analysis increases the risk of type II statistical errors.
- Cross-sectional design
- Data collected nearly 10 years ago
- Sample concerned the first cohort of men treated with RALP at the hospital, so surgical parameters might have improved due to learning curve effects
Cite This Study
Dahl et al. (2020) conducted a cross-sectional in Prostate cancer (n=524). High neuroticism vs. Low neuroticism was evaluated on EPIC-26 domain scores (urinary, bowel, sexual, and hormonal) (p=<0.001). High neuroticism was significantly associated with lower mean scores across all EPIC-26 domains, indicating increased self-reported adverse effects after robot-assisted radical prostatectomy.
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