Key result
Iranian infectious bronchitis virus field isolates are genetically distinct from commonly used vaccine strains, clustering separately despite 90% sequence similarity in the N gene and 3' UTR.
Iranian IBV field isolates are genetically distinct from commonly used vaccine strains, highlighting the need for geographically relevant vaccines.
IBV vaccine mismatch may occur in Iranian flocks; leaves open protective efficacy of current strains pending field trials.
Infectious bronchitis (IB) is an economically important disease of chickens. Due to the emergence of new variants of infectious bronchitis virus (IBV), the control of IB has become a serious problem for the poultry industry worldwide. In the present study, the nucleocapsid gene (N) and 3' untranslated region (UTR) of two IBVs isolated from Iranian poultry farms were sequenced and compared with other IBV strains. Based on nucleotide identity, the N gene and 3' UTR sequences of Iranian IBVs showed 90% similarity to the commonly used IBV vaccine strains, H52 and H120. However, based on phylogenetic analyses, Iranian IBVs were found to cluster separately from the IBV vaccine strains used in Iran as well as other IBVs isolated in China, Australia and the United States. It was concluded that IBVs circulating in Iran are genetically distinct from IBV vaccine strains that have been used in Iran for many years. Therefore, it is important to develop a new vaccine based on these newly identified strains for controlling IB in Iranian poultry farms.
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مردانی et al. (2011) studied Infectious bronchitis virus (IBV) (n=3). Molecular sequencing of N gene and 3' UTR vs. Vaccine strains (H52, H120) and other international isolates was evaluated on Nucleotide sequence similarity and phylogenetic clustering. Iranian infectious bronchitis virus field isolates are genetically distinct from commonly used vaccine strains, clustering separately despite 90% sequence similarity in the N gene and 3' UTR.
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