Stereoselective Synthesis of CF3‐Containing Spirooxindoles via 1,3‐Dipolar Cycloaddition by Dipeptide‐Based Phosphonium Salt Catalysis

This is the authors' abstract. We don't add key points for this paper.

Reported here is an alternative method for asymmetric synthesis of the CF3‐substituted 3,2′‐pyrrolidinyl spirooxindoles via 1,3‐dipolar cycloaddition by employing dipeptide‐based chiral phosphonium salt as a phase‐transfer catalyst. Under the optimal reaction conditions, a variety of CF3‐substituted 3,2′‐pyrrolidinyl spirooxindole derivatives were readily prepared in high yields as a single diastereomer with high enantiomeric access (>20:1 dr and up to 94% ee). magnified image