Key result
The genomic deletion in the cardiomyopathic hamster spans about 30 kb including the first two exons of the delta-sarcoglycan gene, which is the only defective transcript in the heart.
Population
Cardiomyopathic hamster (animal model for autosomal recessive cardiomyopathy)
Comparison
Genomic analysis (delineation of genomic deletion) vs Normal hamster heart
Design
Preclinical
Authors
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Establishes delta-sarcoglycan deletion as basis in hamster model; leaves open relevance to human cardiomyopathy.
The study identifies a ~30 kb genomic deletion encompassing the first two exons of the delta-sarcoglycan gene as the sole transcript defect in the cardiomyopathic hamster model.
Sakamoto et al. (1999) studied Autosomal recessive cardiomyopathy. Genomic deletion of delta-sarcoglycan vs. Normal hamster heart was evaluated on Genomic region deleted and transcript defect. The genomic deletion in the cardiomyopathic hamster spans about 30 kb including the first two exons of the delta-sarcoglycan gene, which is the only defective transcript in the heart.
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