Very Late‐Onset Group BStreptococcusMeningitis, Sepsis, and Systemic Shigellosis due to Interleukin‐1 Receptor–Associated Kinase‐4 Deficiency

We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.