Key result
Various regulatory factors, including 5-azacytidine, microRNAs, cytokines, and the microenvironment, can induce bone-marrow mesenchymal stem cells to differentiate into cardiomyocytes.
Population
Bone-marrow mesenchymal stem cells (BMSCs)
Design
Review
Authors
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Hypothesis-generating for BMSC cardiac regeneration; prospective trials needed before any clinical consideration.
Various regulatory factors, including microRNAs and cytokines, can induce bone-marrow mesenchymal stem cells to differentiate into cardiomyocytes, presenting a promising strategy for cardiac regeneration.
Guo et al. (2018) conducted a review in Cardiac diseases (focus on BMSC differentiation into cardiomyocytes). Regulatory factors (chemicals, microRNAs, cytokines, microenvironment) was evaluated. Various regulatory factors, including 5-azacytidine, microRNAs, cytokines, and the microenvironment, can induce bone-marrow mesenchymal stem cells to differentiate into cardiomyocytes.
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