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14C-labelled citral was applied on four groups of guinea pigs: (a) one sensitized to citral alone; (b) one sensitized to a citral-d-limonene 1 : 1 molar mixture; (c) FCA-treated controls; (d) controls. The most important results concern the amount of labelled material in soluble compared with insoluble skin protein extracts (SPE). In citral-sensitized animals, more label was found in the soluble SPE when citral + limonene was applied to the skin; in citral + limonene sensitized animals, the same trend (i.e. more label in soluble SPE) was found. The possible role of limonene in alleviating the allergic reaction to citral is discussed.
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Barbier et al. (1983) studied this question.
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