Key result
Apolipoprotein CIII was an independent contributor to triglyceride levels (standardized β = 0.230, p<0.01), mediating the effects of ANGPTL8 on triglyceride metabolism.
Case-Control (n=120)
No
ApoCIII may mediate the effects of ANGPTL8 on triglyceride metabolism, though ANGPTL8 levels do not significantly differ between CAD and non-CAD patients.
ApoCIII may mediate ANGPTL8 effects on triglycerides in this case-control study; leaves open causal roles in CAD or therapeutic implications.
BACKGROUND: Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia. Whether any relationship exists between these two important modulators of triglyceride metabolism has not been reported. Besides, whether ANGPTL8 concentration is altered in the patients with coronary artery disease (CAD) is still unclear. METHODS: A hospital-based case-control study was conducted. Sixty-eight CAD subjects and fifty-two nonCAD controls were recruited. Plasma apoCIII, ANGPTL8 was measured. RESULTS: ANGPTL8 and apoCIII concentration exhibited no significant difference between CAD group and nonCAD group. Both ANGPTL8 and apoCIII were significantly correlated with triglyceride level(r = - 0.243, P = 0.008; r = 0.335, P < 0.001, respectively). Regression analysis revealed that apoCIII was an independent contributor to triglyceride level independent of ANGPTL8 concentration (standardized β = 0.230, P < 0.01). CONCLUSION: ApoCIII may mediate the effects of ANGPTL8 on triglyceride metabolism.
No takes yet. Share an insight, caveat, or question.
Luo et al. (2018) conducted a case-control in Coronary artery disease (n=120). Apolipoprotein CIII and Angiopoietin-like protein 8 was evaluated on Independent contribution to triglyceride level (multivariate regression) (standardized β = 0.230, p=<0.01). Apolipoprotein CIII was an independent contributor to triglyceride levels (standardized β = 0.230, p<0.01), mediating the effects of ANGPTL8 on triglyceride metabolism.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: