Key result
Irisin and betatrophin are hypothesized to be linked in a pathway involved in insulin resistance, with potential implications for regenerative capacity and beta cell dedifferentiation in diabetes.
The paper hypothesizes a link between irisin and betatrophin in insulin resistance and their potential implications for regenerative capacity and beta cell dedifferentiation in diabetes.
Hypothesis-generating irisin-betatrophin link in insulin resistance; leaves open beta-cell regenerative implications pending prospective validation.
The discovery of irisin as a novel and promising peptidic hormone has raised hopes regarding the hypothesis that irisin may provide additional benefits, not only for obesity and diabetes, but also for a wide range of pathological conditions since this hormone may prove to be therapeutically and clinically beneficial. In addition, a new hormone, betatrophin, has recently been identified by Yi and coworkers. Both hormones are connected by a new pathway clearly involved in insulin resistance. We hypothesize here how these hormones may be linked and their possible implications in both aged-reduced restricted regenerative capacity and dedifferentiated β cells of diabetic patients.
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Sanchis‐Gomar et al. (2013) conducted a review in Obesity and diabetes. p38–PGC-1α–irisin–betatrophin axis was evaluated. Irisin and betatrophin are hypothesized to be linked in a pathway involved in insulin resistance, with potential implications for regenerative capacity and beta cell dedifferentiation in diabetes.
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