Key result
Endogenous NAIP protein is strongly expressed in motor neurons of normal brains and is not altered in the remaining motor neurons of patients with amyotrophic lateral sclerosis.
Observational
NAIP is strongly expressed in human motor neurons but its expression is not altered in ALS, suggesting its anti-apoptotic function may be important in motor neurons but not directly implicated in ALS pathology.
The neuronal apoptosis inhibitory protein (NAIP) is known to have anti-apoptotic functions, and its gene is often mutated in severe cases of spinal muscular atrophy (SMA), a disease characterized by motor neuron degeneration. In this study, we examined the distribution of the endogenous NAIP protein in normal human spinal cord and brain tissue by using a polyclonal antibody against NAIP. Immunohistochemical staining demonstrated that NAIP is strongly expressed in anterior horn and motor cortex neurons of normal brains, and it is not altered in the remaining motor neurons of patients with amyotrophic lateral sclerosis (ALS). NAIP is also located in human fetal neurons and in adult choroid plexus cells. These results suggest that the anti apoptotic molecule NAIP may be important in motor neurons, but it specifically does not appear to be altered in ALS.
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Pari et al. (2000) conducted an observational in Amyotrophic lateral sclerosis (ALS). NAIP protein expression vs. Normal brain and spinal cord tissue was evaluated on Distribution of endogenous NAIP protein. Endogenous NAIP protein is strongly expressed in motor neurons of normal brains and is not altered in the remaining motor neurons of patients with amyotrophic lateral sclerosis.
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