Key result
Mitochondrial dysfunction acts as a central upstream defect inflicted on the heart by diabetes, contributing to the multifactorial nature of diabetic cardiomyopathy.
This review highlights mitochondrial dysfunction as a central upstream defect in diabetic cardiomyopathy and identifies key knowledge gaps for future research.
Mitochondrial focus may guide mechanistic research in diabetic cardiomyopathy; leaves open whether targeting alters clinical outcomes.
This Forum addresses the role of mitochondrial dysfunction in the multifactorial nature of diabetic cardiomyopathy (DCM) from multiple angles. Contributors deliver a diverse and in-depth view of the state-of-the-art in DCM, from bench to bedside. What emerges is a picture of mitochondrial dysfunction as a central upstream defect, inflicted on the heart by diabetes. Collectively, the authors pinpoint high-value knowledge gaps, propose new conceptual frameworks, and highlight understudied, but promising, research themes.
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Aon et al. (2015) conducted a review in Diabetic cardiomyopathy. Mitochondrial dysfunction was evaluated. Mitochondrial dysfunction acts as a central upstream defect inflicted on the heart by diabetes, contributing to the multifactorial nature of diabetic cardiomyopathy.
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