Experimental study demonstrates regioselective synthesis of chromone derivatives from 4-hydroxycoumarins and propargyl alcohols using iron(II) iodide, highlighting an efficient tandem pathway.
The reaction of 4-hydroxycoumarins with propargyl alcohols was studied by using FeI2. Chromone derivatives were obtained by a FeI2-promoted sequential transformation involving dehydrative coupling followed by iodocyclization. The FeI2-mediated iodocyclization of the coupling intermediates proceeded in a regioselective 6-endo-dig manner to give the chromone derivatives without the formation of coumarin derivatives.
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Miyabe et al. (2025) studied this question.
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