Key result
Evidence suggests that the primary biochemical defect underlying heart failure may be in excitation-contraction coupling, specifically the role of calcium as a mediator of contraction.
This review highlights excitation-contraction coupling and calcium handling as the likely primary biochemical defects underlying the onset of heart failure.
Supports calcium handling research in heart failure; hypothesis-generating and should not yet change practice.
As various pathways have been followed in the search for the biochemical defect underlying the onset of failure, evidence has been obtained that changes in energy metabolism and in protein synthesis may contribute but do not play the primary causative role. A third, more promising, possibility is that the defect may be in excitation-contraction coupling, specifically in the role of calcium as a mediator of contraction.
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Peter E. Pool (1971) conducted a review in Heart Failure. Evidence suggests that the primary biochemical defect underlying heart failure may be in excitation-contraction coupling, specifically the role of calcium as a mediator of contraction.
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