Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2concentrations in young men

Background: Reduction in central arterial compliance is an independent risk factor for cardiovascular disease, and is caused by high-intensity resistance training.The thromboxane has both potent vasoconstrictive and platelet aggregation effects, and is associated with cardiovascular diseases.However, whether thromboxane is involved in resistance training-induced decrease in central arterial compliance is unclear.The present study aimed to investigate relationships between circulating thromboxane levels and central arterial compliance in both cross-sectional and longitudinal (i.e., resistance training) designs.Methods and results: First, in a cross-sectional study, we assessed association between circulating thromboxane concentrations and central arterial compliance in 63 young men, who showed significant negative correlation between those parameters.Second, in a longitudinal study, we examined effects of high-intensity resistance training on circulating thromboxane concentrations and central arterial compliance and relationship among changes from baseline in those parameters.Young sedentary men were assigned to control (n Z 7) or training (n Z 17) groups.Subjects in training group underwent four-week supervised high-intensity resistance training.