Key result
Preeclampsia increases future cardiovascular disease risk in women by 2- to 4-fold, representing an underrecognized form of cardiorenal syndrome driven by persistent endothelial dysfunction.
Preeclampsia should be recognized as a form of Type 5 Cardiorenal Syndrome, necessitating early identification and management to mitigate long-term cardiovascular and kidney disease risk in women.
Preeclampsia may flag elevated long-term cardiorenal risk in women; leaves open whether targeted interventions alter outcomes.
BACKGROUND: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors. SUMMARY: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. It describes the pathophysiology and current understanding of biomarkers that form the molecular signature for long-term endothelial dysfunction in preeclamptic women. Finally, it describes strategies for early identification and management of women with preeclampsia with elevated risk for cardiovascular and kidney disease. Key Messages: Future rigorous studies on cardiovascular risk modification in this phenotype of disease are essential to reduce the burden of cardiovascular and kidney disease, in women with preeclampsia.
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Rangaswami et al. (2018) conducted a review in Preeclampsia. Preeclampsia vs. Uncomplicated pregnancy was evaluated. Preeclampsia increases future cardiovascular disease risk in women by 2- to 4-fold, representing an underrecognized form of cardiorenal syndrome driven by persistent endothelial dysfunction.
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