Key result
MMP-7 mRNA expression was markedly higher in invasive prostatic cancer tissues compared to normal prostate and benign prostatic hyperplasia, suggesting a role in tumor invasion and metastasis.
Observational
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Should not change prostate cancer practice; leaves open MMP-7 as therapeutic target pending prospective validation.
BACKGROUND: Matrix metalloproteinases-7 (MMP-7), one of an extracellular matrixdegrading metalloproteinase, play an important role tumor invasion and metastasis. We investigated localization, biochemical characterization and mRNA expression of MMP-7 in prostate tissues. METHODS: Immunohistochemical method, SDS-polyacrylamide gel electrophoresis and northern blot analysis were performed using tissues of prostatic cancer, BPH and normal prostate. RESULTS: A latent proenzyme with Mr28,000 of MMP-7 was detected in the ductal epithelial cells of BPH and in the cytoplasm of cancer cell of the prostate. The ratio of mRNA expression in MMP-7/beta-actin was significantly higher in the tissue of the invasive prostatic cancer than those of normal prostate and BPH in northern blot analysis. CONCLUSIONS: These results suggest that MMP-7 may participate in the function of exocrine gland of normal prostate by preventing glandular obstruction and may play a role in invasion and metastasis of prostatic cancer.
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Hashimoto et al. (1997) conducted an observational in Prostatic cancer and benign prostatic hyperplasia. MMP-7 expression vs. Normal prostate and BPH tissues was evaluated on MMP-7/beta-actin mRNA expression ratio. MMP-7 mRNA expression was markedly higher in invasive prostatic cancer tissues compared to normal prostate and benign prostatic hyperplasia, suggesting a role in tumor invasion and metastasis.
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