What question did this study set out to answer?

To evaluate the expression of matrix metalloproteinase-7 (MMP-7) in invasive breast cancer and examine its relationship with clinicopathological characteristics, survival, and key molecular markers.

April 1, 2005Apmis

The multifunctional role of the immunohistochemical expression of MMP‐7 in invasive breast cancer

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Authors

EMEugenia MylonaUniversity of Ioannina AKAmalia KapranouAthens Naval & Veterans Hospital JMJ. MavrommatisNational and Kapodistrian University of Athens

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Implication

Observational study reveals dual invasion and low-grade tumor associations for MMP-7 in invasive breast cancer, suggesting a multifunctional role in tumor progression.

Key Points

To evaluate the expression of matrix metalloproteinase-7 (MMP-7) in invasive breast cancer and examine its relationship with clinicopathological characteristics, survival, and key molecular markers.
Conducted an immunohistochemical analysis on invasive breast carcinoma samples (N=177).
Evaluated MMP-7 expression in malignant epithelial and stromal compartments in relation to p53, c-erbB-2, topoIIa, MMP-2, uPAR, and beta-catenin.
Cytoplasmic MMP-7 immunoreactivity was identified in 54.2% (96/177) of cancer cells and 47.5% (84/177) of tumor stromal cells.
Cancer cell MMP-7 expression showed inverse correlations with nuclear grade (p=0.049), topoIIa (p=0.03), and abnormal beta-catenin (p=0.047).
MMP-7 expression in tumor and stromal cells correlated positively with uPAR (p=0.033 and p=0.027, respectively), and stromal MMP-7 correlated with stromal MMP-2 (p=0.044).

Cite This Study

Mylona et al. (2005) studied this question.

synapsesocial.com/papers/6aa2bffe3e2844b40732321a https://doi.org/10.1111/j.1600-0463.2005.apm_02.x

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Implication

Observational study reveals dual invasion and low-grade tumor associations for MMP-7 in invasive breast cancer, suggesting a multifunctional role in tumor progression.

The multifunctional role of the immunohistochemical expression of MMP‐7 in invasive breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

The multifunctional role of the immunohistochemical expression of MMP‐7 in invasive breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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