Key result
Co-injection of heparin with rAAV2 leads to a significantly higher and more homogeneous distribution of transduced cells in the mammalian brain.
Co-injecting rAAV2 with heparin maximizes transduction efficiency and viral spread in the mammalian central nervous system.
No takes yet. Share an insight, caveat, or question.
May enhance rAAV2 brain delivery in models; leaves open translation to human CNS gene therapy.
Mastakov et al. (2002) studied Gene delivery into the CNS. rAAV2 co-injected with heparin vs. rAAV5 or rAAV2 without heparin was evaluated on Distribution of transduced cells. Co-injection of heparin with rAAV2 leads to a significantly higher and more homogeneous distribution of transduced cells in the mammalian brain.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: