Key result
During a series of 1,200 maximal twitches, developed tension dropped much more slowly in dystrophic mouse muscles compared to normal muscles (final output relative to initial: 70% vs 10%).
Population
Excised gastrocnemii of normal and dystrophic mice
Comparison
Direct stimulation in long series of isometric… vs Normal mouse muscles compared to dystrophic…
Design
Preclinical
Authors
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Does not support clinical translation in dystrophy; leaves open mechanistic studies of fatigue resistance in models.
Absolute Event Rate: 70% vs 10%
Dystrophic mouse muscles exhibit a qualitatively distinct fatigue pattern with slower tension drop compared to normal muscles during prolonged stimulation.
Sandow et al. (1962) studied Dystrophic myopathy. Series of 1,200 maximal twitches vs. Normal mouse muscles was evaluated on Final output relative to initial developed tension. During a series of 1,200 maximal twitches, developed tension dropped much more slowly in dystrophic mouse muscles compared to normal muscles (final output relative to initial: 70% vs 10%).
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