Key result
Plasmapheresis successfully reduced serum triglycerides from 9755 mg/dL to 559 mg/dL and resolved symptoms in a pregnant woman with presumed chylomicronemia syndrome.
Why the study?
Chylomicronemia syndrome is a rare and frequently misdiagnosed condition that can be aggravated by pregnancy.
Case Report (n=1)
No
This case highlights the diagnostic challenge of chylomicronemia syndrome in pregnancy and supports the safety of therapeutic plasmapheresis in this setting.
May offer a treatment option for severe hypertriglyceridemia in pregnancy; single case leaves open need for prospective studies before wider use.
Hypertriglyceridemia is a frequent cause of acute pancreatitis. Levels higher than 1000 mg/dL are often associated with a genetic predisposition that can be aggravated by other factors such as pregnancy and poorly controlled diabetes. The authors report a 19-year-old primigravida that presented with abdominal pain, emesis and a pruritic rash, along with severely increased plasma triglyceride levels. Therapeutic plasmapheresis was proposed in the setting of a presumed acute pancreatitis. Chylomicronemia syndrome is a rare and frequently misdiagnosed pathology that can evolve with abdominal pain, vomiting and a specific cutaneous rash designated as eruptive xanthomatosis. This case report illustrates the challenges of achieving a correct diagnosis for rare conditions and corroborates the safety of plasmapheresis during pregnancy.
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Parente et al. (2021) conducted a case report in Chylomicronemia Syndrome in Pregnancy (n=1). Plasmapheresis was evaluated on Serum triglycerides level. Plasmapheresis successfully reduced serum triglycerides from 9755 mg/dL to 559 mg/dL and resolved symptoms in a pregnant woman with presumed chylomicronemia syndrome.
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