Key result
Impaired systolic and diastolic blood pressure recovery after standing were associated with increased mortality in Alzheimer's disease (systolic HR 2.9, p=0.039; diastolic HR 5.5, p=0.002).
Why the study?
Impaired blood pressure recovery after standing is linked to cognitive function and mortality in people without dementia, but its role in Alzheimer's disease is unknown.
Does impaired orthostatic blood pressure recovery predict cognitive decline and mortality in patients with mild-to-moderate Alzheimer's disease?
Cohort (n=55)
Does impaired orthostatic blood pressure recovery predict cognitive decline and mortality in patients with mild-to-moderate Alzheimer's disease?
Hazard Ratio: 2.9 (95% CI 1.1–7.8)
p-value: p=0.039
Impaired orthostatic blood pressure recovery after 1 minute of standing is a predictor of cognitive decline and mortality in patients with mild-to-moderate Alzheimer's disease.
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Impaired orthostatic BP recovery may flag higher mortality risk in AD; hypothesis-generating and requires prospective validation before any practice change.
Heus et al. (2020) conducted a cohort in Alzheimer's disease (n=55). Impaired blood pressure recovery (<100%) after 1 minute of standing vs. Unimpaired blood pressure recovery (≥100%) was evaluated on All-cause mortality (systolic) (HR 2.9, 95% CI 1.1-7.8, p=0.039). Impaired systolic and diastolic blood pressure recovery after standing were associated with increased mortality in Alzheimer's disease (systolic HR 2.9, p=0.039; diastolic HR 5.5, p=0.002).
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