Key result
In rats with brain injury, PCPA at 200-300 mg/kg ameliorated the depression of local cerebral glucose utilization and completely prevented increases in 5-HT and its metabolite.
Why the study?
Does p-chlorophenylalanine improve local cerebral glucose utilization in rats with focal cortical freezing lesions?
Population
Rats with focal cortical freezing lesions (traumatized brain) and intact brain
Comparison
p-chlorophenylalanine in doses up to 300 mg/kg vs Untreated animals (intact and injured brain)
Design
Preclinical
Authors
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Hypothesis-generating for serotonergic modulation in experimental brain injury; leaves open translation to clinical neuroprotection.
Does p-chlorophenylalanine improve local cerebral glucose utilization in rats with focal cortical freezing lesions?
Inhibition of serotonin synthesis with PCPA ameliorates the depression of local cerebral glucose utilization following brain injury in rats, suggesting a role for serotonin in injury-induced functional alterations.
Pappius et al. (1988) studied Traumatized brain. p-chlorophenylalanine (PCPA) vs. Untreated animals was evaluated on Local cerebral glucose utilization (LCGU) and serotonin (5-HT) metabolism. In rats with brain injury, PCPA at 200-300 mg/kg ameliorated the depression of local cerebral glucose utilization and completely prevented increases in 5-HT and its metabolite.
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