Key result
Among smokeless tobacco users presenting with acute coronary syndrome, single-vessel disease was the most common angiographic finding (47.8%), predominantly involving the right coronary artery (37.1%).
Why the study?
Smokeless tobacco users with ACS are more likely to develop significant CAD with multi-vessel involvement, highlighting the need to evaluate their angiographic profiles.
What is the coronary angiographic profile of smokeless tobacco users presenting with acute coronary syndrome?
Cross-Sectional (n=159)
No
What is the coronary angiographic profile of smokeless tobacco users presenting with acute coronary syndrome?
Smokeless tobacco users presenting with ACS frequently exhibit single vessel disease, often involving the right coronary artery, highlighting the significant cardiovascular risk of smokeless tobacco.
May warrant heightened CAD surveillance in smokeless tobacco users with ACS; leaves open prospective validation of causality.
Smokeless tobacco users with acute coronary syndrome (ACS) at tertiary care cardiac centers are more likely to develop significant coronary artery disease (CAD). With multi-vessel involvement, highlighting its significant risk factor. Objectives: To determine the frequency of coronary angiographic profiles in smokeless tobacco users with ACS at a cardiac center. Methods: A study involving 159 smokeless tobacco users aged 18-70 with acute coronary syndrome was conducted at the National Institute of Cardiovascular Diseases (NICVD) Karachi from Mar 2022 to Jan 2024, recording demographic data such as gender, age, height, and weight. Before an angiography procedure, the patient's medical history, including hypertension, diabetes, family history, and obesity, was reviewed, along with their smokeless tobacco use, recording type, frequency, and duration. Results: A study involving 159 smokeless tobacco users aged 18-70 years, with a mean age of 46.64 ± 10.186, included 134 male (84.3%) and 25 female (15.7%). The study revealed that male accounted for 63 (39.62%) of the total ACS with Single vascular disease (SVD), while unstable angina was typical in 52 (32.70%) cases. The study found a significant association between age groups, ACS type, culprit artery, and tobacco use on the day of ACS (p=0.004, 0.027, 0.044, and 0.024), respectively. However, no significant association was seen between gender, tobacco type, and risk variables. Conclusions: It was concluded that smokeless tobacco significantly contributes to ACS, with a high percentage of single vessel blockage involving RCA, and that duration and number of use also contribute to ACS.
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Sahrish et al. (2025) conducted a cross-sectional in Acute Coronary Syndrome (n=159). Smokeless tobacco use was evaluated on Frequency of single-vessel disease (SVD). Among smokeless tobacco users presenting with acute coronary syndrome, single-vessel disease was the most common angiographic finding (47.8%), predominantly involving the right coronary artery (37.1%).
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