Further Studies on Intoxication With Vitamin D

Article1 January 1937FURTHER STUDIES ON INTOXICATION WITH VITAMIN DI. E. STECK, M.D., H. DEUTSCH, A.B., C. I. REED, Ph.D., H. C. STRUCK, Ph.D.I. E. STECK, M.D.Search for more papers by this author, H. DEUTSCH, A.B.Search for more papers by this author, C. I. REED, Ph.D.Search for more papers by this author, H. C. STRUCK, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-7-951 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the extensive application of massive doses of vitamin D as a therapeutic agent in various clinical conditions1, 2, 3, 4, 5, 6, 7 numerous criticisms have arisen which may be summarized as follows:1. Hypervitaminosis D may produce symptoms of hyperparathyroidism.2. The therapeutic use of vitamin D is rational only in conditions of known deficiency.3. Animals experimentally treated with vitamin D concentrates have shown extensive calcium deposits in various tissues, and other pathological changes have been found. There is, thus, danger of permanent injury to human subjects.It is not the purpose of this paper to discuss...Bibliography1. REEDSEED CIL: The treatment of clinical tetany with irradiated ergosterol, Endocrinology, 1933, xvii, 136-148. Google Scholar2. RAPPAPORTREED BZCI: Viosterol of high potency in seasonal hay fever and allergy, Jr. Am. Med. Assoc., 1933, ci, 105-109. CrossrefGoogle Scholar3. RAPPAPORTHATHAWAYREEDSTRUCK BZMLCIHC: The treatment of hay fever and asthma with viosterol of high potency, Jr. Allergy, 1934, v, 541-553. CrossrefGoogle Scholar4. REED CI: The symptoms of viosterol overdosage in human subjects, Jr. Am. Med. Assoc., 1934, cii, 1745-1748. CrossrefGoogle Scholar5. DREYERREED ICI: The treatment of arthritis with massive doses of vitamin D, Arch. Phys. Therapy, 1935, xvi, 537-540. Google Scholar6. CRIMM PD: Vitamin therapy in pulmonary tuberculosis, Am. Rev. Tuberc., 1932, xxvi, 112-123; Ibid., 1933, xxviii, 202-216; Am. Jr. Med. Sci., 1934, clxxxvii, 557-562; Jr. Lab. and Clin. Med., 1934, xix, 966-971. Google Scholar7. VRTIAKLANG EGRS: Observations on the treatment of chronic arthritis with vitamin D, Jr. Am. Med. Assoc., 1936, cvi, 1162-1163. CrossrefGoogle Scholar8. SHELLING DH: The parathyroids in health and disease, 1935, C. V. Mosby Co., St. Louis, Mo. Google Scholar9. BILLS CE: Physiology of the sterols, including vitamin C, Physiol. Rev., 1935, xv, 1-97. CrossrefGoogle Scholar10. REEDDILLMANTHACKERKLEIN CILMEARI: The calcification of tissues by excessive doses of irradiated ergosterol, Jr. Nutr., 1933, vi, 371-381. CrossrefGoogle Scholar11. APPELROT S: Hypervitaminosis D and blood pressure in dogs, Am. Jr. Physiol., 1933, cv, 294. CrossrefGoogle Scholar12. REEDTHACKERDILLMANWELCH CIEALMJW: The effects of irradiated ergosterol on the metabolism of normal dogs, Jr. Nutr., 1933, vi, 355-370. CrossrefGoogle Scholar13. HATHAWAYRAPPAPORTREEDSTRUCK MLBZCIHC: A study of blood constituents in pollenosis with and without treatment, Jr. Allergy, 1936, viii, 1-21. CrossrefGoogle Scholar14. THATCHER L: Hypervitaminosis D, Lancet, 1936, i, 20-22. CrossrefGoogle Scholar15. KERRCARR WJJL: Personal communications. Google Scholar16. HAMLEWIS AWMD: Experimental intimal sclerosis of the coronary arteries of rats, Arch. Path., 1934, xvii, 356-361. Google Scholar17. DEUTSCHREEDSTRUCK HCIHC: The rôle of the thyroid in the calorigenic action of vitamin D, Am. Jr. Physiol., 1936, cxvii, 1. Google Scholar18. GELFAN S: The effect of viosterol upon oxygen consumption of frog's muscle, Am. Jr. Physiol., 1935, cxiii, 464-466. CrossrefGoogle Scholar19. COWDRYSCOTT EVGH: Effect on monkeys of small doses of a concentrated preparation of viosterol, Arch. Path., 1936, xxii, 1-23. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication September 26, 1936.From the Departments of Medicine and of Physiology, College of Medicine, University of Illinois, Chicago.†This investigation at various stages has been supported in part by grants from Mead Johnson and Company; the Graduate School Research Fund, University of Illinois; the American Academy of Arts and Sciences; the Wisconsin Alumni Research Foundation; the Committee on Therapeutics of the American Medical Association; and the Phi Rho Sigma Medical Fraternity. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin D toxicosisHypothesis: etiology of atherosclerosis and osteoporosis: are imbalances in the calciferol endocrine system implicated?Hypercalcemia of malignancy: pathophysiology, diagnosis and treatmentDisorders of Mineral Metabolism in MalignancyRenal Function in Treated Hypoparathyroidism a Possible Direct Nephrotoxic Effect of Vitamin DACUTE RENAL FAILURE IN THE DOG AND CATVITAMIN D AND CARDIOVASCULAR, RENAL, AND BRAIN DAMAGE IN INFANCY AND CHILDHOODMETASTATIC CALCIFICATION OF SOFT TISSUE ON OVERDOSAGE OF VITAMIN DThe Calciferol Requirements of Patients with Surgical HypoparathyroidismANTHONY W. IRELAND, M.B., JOHN S. CLUBB, M.B., FRANCIS C. NEALE, PH.D., SOLOMON POSEN, M.D., F.R.A.C.P., THOMAS S. REEVE, M.B.Renal complications of neoplastic diseaseDas Krankheitsbild der „idiopathischen“ Hypercalcämie, eine chronische Vitamin D-IntoxikationDie Pathologie der Avitaminosen und HypervitaminosenInfluence of Dietary Calcium, Phosphorus and Vitamin D3 on Ca45, P32 and Sr85 Uptake by ChicksCalcium and the kidneyYitamin D2 (Calciferol) IntoxicationDisturbed Water-reabsorption by the Renal Tubules in two Patients with HypercalcaemiaHypercalcemia in Hodgkin's DiseaseReversible metastatic calcification associated with excessive milk and alkali intakeVitamin D poisoning with metastatic calcificationVitamin D Intoxication in a Case of Parathyropriral TetanySection 4-Vitamin Requirements and AvitaminosesTREATMENT OF LUPUS VULGARIS WITH CALCIFEROLTREATMENT OF LUPUS VULGARIS WITH CALCIFEROLÜber D-Vitamin-VergiftungLupus Vulgaris Treated with CalciferolFurther observations on the use of single massive doses of vitamin D in the prevention of ricketsSafety of large doses of vitamin D in theprevention and treatment of rickets in infancyPrevention of rickets with single massivedoses of vitamin DVHypervitamin therapy in surgical practiceLiteraturübersicht 1 January 1937Volume 10, Issue 7Page: 951-964KeywordsAlumniCalciumGraduate medical educationHyperparathyroidismIntoxicationResearch fundingVitamin DVitamin D deficiency ePublished: 1 December 2008 Issue Published: 1 January 1937 PDF downloadLoading ...