Key result
Upper arm cuff occlusion resulted in a greater decrease in carotid-radial pulse wave velocity at 1 minute compared to lower arm occlusion (-11.5% vs -6.8%, P=0.02).
Why the study?
Does upper arm cuff occlusion compared to lower arm cuff occlusion cause greater changes in carotid-radial pulse wave velocity?
Cross-Sectional (n=65)
Does upper arm cuff occlusion compared to lower arm cuff occlusion cause greater changes in carotid-radial pulse wave velocity?
Upper arm cuff occlusion induces a greater decline in carotid-radial pulse wave velocity compared to lower arm occlusion, and this hyperemic response lessens with increasing cardiovascular risk.
UNLABELLED: Carotid-radial pulse wave velocity (PWV) normally decreases following release of upper arm cuff occlusion (hyperemia). Lower arm (LA) elicits less brachial artery dilation than upper arm (UA) occlusion but more closely reflects endothelial function. Using applanation tonometry, we compared changes (Δ) in PWV induced by UA and LA hyperemia in 65 healthy participants. Pulse wave velocity was measured serially. Both techniques decreased PWV maximally at 1 minute with gradual return to baseline by 9 minutes. ΔPWV(1min) was greater for UA than LA occlusion (-11.5% vs -6.8%, P = .02). Multivariate analysis showed arm location independently related to ΔPWV (P = .036). In participants with variable cardiovascular risk, PWV decline lessened with increasing Framingham risk for both techniques. IN CONCLUSION: UA and LA occlusion decrease PWV maximally at 1 minute after release of arterial occlusion. PWV(1min) decline are more marked after UA than LA occlusion and progressively lessens with increasing Framingham risk.
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Kamran et al. (2011) conducted a cross-sectional in Healthy participants and variable cardiovascular risk (n=65). Upper arm cuff occlusion vs. Lower arm cuff occlusion was evaluated on Change in pulse wave velocity at 1 minute (ΔPWV(1min)) (p=0.02). Upper arm cuff occlusion resulted in a greater decrease in carotid-radial pulse wave velocity at 1 minute compared to lower arm occlusion (-11.5% vs -6.8%, P=0.02).
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