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September 6, 2026Social Cognitive and Affective NeuroscienceOpen Access

Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making

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Authors

PCPatricia ChristianJKJakob KaiserGKGeorgia Eleni Kapetaniou

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Overview

Experimental study reveals prefrontal stimulation uncouples heart rate arousal from fairness choices, suggesting cortical modulation integrates emotion and cognitive trade-offs.

Key Points

  • Determine which brain regions integrate autonomic physiological reactions, such as heart rate changes elicited by norm violations, into normative value computations during decision making.
  • Applied excitatory brain stimulation over the ventromedial prefrontal cortex during an Ultimatum Game paradigm.
  • Tracked physiological heart rate responses and assessed post-decision confidence across varying levels of monetary inequality.
  • Unfair monetary splits triggered marked physiological increases in heart rate responses.
  • Excitatory stimulation of the ventromedial prefrontal cortex reduced behavioral aversion to disadvantageous inequality and increased post-decision confidence after accepting unfair offers.
  • Prefrontal excitation reduced unfairness sensitivity by uncoupling heart rate reactivity from choice behavior rather than suppressing cardiac reactions directly.

Cite This Study

Christian et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1e1f28139818eab20daehttps://doi.org/10.1093/scan/nsag075
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