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September 6, 2026Journal of Animal Science

Human milk-derived Limosilactobacillus reuteri improved growth performance of weaned pigs by modulating systemic immune responses and enhancing intestinal health

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Authors

HKHyunjin KyoungSHSewon HaKPKyeong Il Park

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Overview

Controlled trial reveals improved growth and enhanced intestinal health in weaned pigs fed human milk-derived Limosilactobacillus reuteri, indicating an alternative to antibiotics in swine production.

Key Points

  • To assess the effects of human milk-derived Limosilactobacillus reuteri dietary supplementation on growth performance, diarrhea rates, systemic immunity, and gut health in weaned pigs.
  • Weaned pigs were fed either a basal control diet or a diet supplemented with human milk-derived Limosilactobacillus reuteri (REU) across a 28-day period.
  • Assessed average daily gain, feed efficiency, diarrhea frequency, serum cytokines, ileal tissue morphology, and tight junction gene expression.
  • Supplementation with REU improved average daily gain during days 1 to 7 and 15 to 28 (P = 0.046) and overall feed efficiency (P = 0.046), with a trend toward reduced diarrhea incidence (P = 0.060).
  • REU reduced serum interleukin-6 on day 7 (P = 0.014) and day 14 (P = 0.027), TNF-α on day 7 (P = 0.033), and TGF-β1 on day 14 (P = 0.008), while raising day 28 serum total protein (P = 0.034).
  • Pigs receiving REU exhibited upregulated ileal claudin-1 (P = 0.002) and interferon-γ (P = 0.032), downregulated interleukin-8 (P = 0.004), and tended to have increased ileal villus height (P = 0.062).

Cite This Study

Kyoung et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1e3328139818eab20dfchttps://doi.org/10.1093/jas/skag276
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Also Consider

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  1. 1Biosynthetic reuterin improved the intestinal health in pigs2026
  2. 2Limosilactobacillus reuteri alleviates weaned stress by improving immune function and gut microbiota in piglets2024 · 15 citations
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  4. 4Effect of Ningxiang pig-derived Lactobacillus reuteri supplementation on the growth performance, lipid metabolism, and gut microbiota of finishing pigs2025 · 5 citations
  5. 5Maternal supplementation with Lactobacillus reuteri enhances colostrum sIgA secretion and immune function of offspring2026