What does this research mean for the field?

Invasive Streptococcus dysgalactiae subspecies equisimilis (iSDSE) infections significantly increased in Denmark from 2014 to 2024, driven by specific dominant genetic clusters that exhibit localized high erythromycin resistance. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate national incidence trends of invasive Streptococcus dysgalactiae subsp. equisimilis (iSDSE) infections over a decade and characterize the genomic structure and antimicrobial resistance profile of circulating isolates.

September 6, 2026EurosurveillanceOpen Access

Emerging trends in invasive Streptococcus dysgalactiae subsp. equisimilis infections in Denmark, 2014 to 2024: a nationwide genomic and registry-based study

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Authors

JGJana Grüttner ARAoife Ronayne RSRaphael N. Sieber

Discussion

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Overview

Nationwide registry-based study reveals rising invasive Streptococcus dysgalactiae incidence with expanding resistant lineages in Danish patients, highlighting the need for genomic tracking.

Key Points

To evaluate national incidence trends of invasive Streptococcus dysgalactiae subsp. equisimilis (iSDSE) infections over a decade and characterize the genomic structure and antimicrobial resistance profile of circulating isolates.
Retrospectively identified invasive group C, group G, and S. dysgalactiae infections using Danish national register data (2014–2024) to calculate overall and sex- and age-stratified annual incidences.
Conducted whole-genome sequencing on N=1,223 voluntary laboratory surveillance isolates collected between August 2020 and September 2022 to evaluate genomic clusters, sequence types, and antimicrobial resistance determinants.
Tested phenotypic antimicrobial susceptibility against penicillin, erythromycin, and clindamycin alongside genomic resistance gene identification.
Annual iSDSE incidence rose significantly from 2014 to 2024 (linear trend p < 0.001), fluctuating between 10.3 and 16.4 cases per 100,000 population and peaking in 2023, with higher rates observed among males and older individuals.
Nearly 75% of the 1,223 sequenced isolates grouped into four of 14 genetic clusters, with ST20 and ST17 emerging as the dominant sequence types and stG62647 representing the primary emm-type.
All isolates were phenotypically susceptible to penicillin, but approximately 10% exhibited resistance to erythromycin and clindamycin, with one cluster showing 57% (39/68) erythromycin resistance linked to the ermA gene.

Cite This Study

Grüttner et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1e3328139818eab20fb0 https://doi.org/10.2807/1560-7917.es.2026.31.35.2500714

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September 6, 2026EurosurveillanceOpen Access

Emerging trends in invasive Streptococcus dysgalactiae subsp. equisimilis infections in Denmark, 2014 to 2024: a nationwide genomic and registry-based study

View Full Paper

Ask AI

Bookmark

Authors

JGJana Grüttner ARAoife Ronayne RSRaphael N. Sieber

Discussion

Member takes

Overview

Nationwide registry-based study reveals rising invasive Streptococcus dysgalactiae incidence with expanding resistant lineages in Danish patients, highlighting the need for genomic tracking.

Key Points

To evaluate national incidence trends of invasive Streptococcus dysgalactiae subsp. equisimilis (iSDSE) infections over a decade and characterize the genomic structure and antimicrobial resistance profile of circulating isolates.
Retrospectively identified invasive group C, group G, and S. dysgalactiae infections using Danish national register data (2014–2024) to calculate overall and sex- and age-stratified annual incidences.
Conducted whole-genome sequencing on N=1,223 voluntary laboratory surveillance isolates collected between August 2020 and September 2022 to evaluate genomic clusters, sequence types, and antimicrobial resistance determinants.
Tested phenotypic antimicrobial susceptibility against penicillin, erythromycin, and clindamycin alongside genomic resistance gene identification.
Annual iSDSE incidence rose significantly from 2014 to 2024 (linear trend p < 0.001), fluctuating between 10.3 and 16.4 cases per 100,000 population and peaking in 2023, with higher rates observed among males and older individuals.
Nearly 75% of the 1,223 sequenced isolates grouped into four of 14 genetic clusters, with ST20 and ST17 emerging as the dominant sequence types and stG62647 representing the primary emm-type.
All isolates were phenotypically susceptible to penicillin, but approximately 10% exhibited resistance to erythromycin and clindamycin, with one cluster showing 57% (39/68) erythromycin resistance linked to the ermA gene.

Cite This Study

Grüttner et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1e3328139818eab20fb0 https://doi.org/10.2807/1560-7917.es.2026.31.35.2500714

View Full Paper

Ask AI

Bookmark