What does this research mean for the field?

A novel biventricular tracking approach is a feasible and highly reproducible method for assessing right ventricular strain, successfully identifying reduced right ventricular free-wall strain in patients with cardiac amyloidosis compared to controls. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Evaluate the feasibility, regional patterns, and reproducibility of a continuous biventricular tracking approach for right ventricular strain assessment in cardiac amyloidosis.

September 6, 2026Clinics and PracticeOpen Access

An Alternative Biventricular Tracking Approach for Assessment of Right Ventricular Strain in Cardiac Amyloidosis

Q: What are the key findings of this study?

The investigational biventricular tracking approach yielded more negative global RV strain values compared with conventional RV strain in patients with amyloidosis (-15.3% vs -13.8%, p=0.003).

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Cardiac amyloidosis (n=64). Intervention: Investigational biventricular tracking approach vs. Conventional RV strain. Primary outcome: Global RV strain in patients with amyloidosis (p=0.003).

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Key result

Biventricular tracking yields ~1.5% more negative global RV strain than conventional assessment in amyloidosis.

P=0.003
n=64

Why the study?

Right ventricular strain assessment in cardiac amyloidosis remains challenging due to complex geometry and conventional speckle-tracking limitations, prompting evaluation of an alternative continuous biventricular tracking pathway.

Does an investigational biventricular tracking approach provide feasible and reproducible assessment of right ventricular strain compared to conventional methods in patients with cardiac amyloidosis?

Population

32 cardiac amyloidosis patients and 32 matched controls

Comparison

Investigational biventricular tracking approach vs conventional RV strain

Design

Retrospective case-control study

Authors

MLMarina LeitmanTel Aviv University VTVladimir TyomkinAssaf Harofeh Medical Center SFShmuel FuchsNational Archives and Records Administration

Discussion

Member takes

Implication

Biventricular tracking may refine RV strain assessment in amyloidosis; hypothesis-generating and should not yet change practice.

Key Points

Evaluate the feasibility, regional patterns, and reproducibility of a continuous biventricular tracking approach for right ventricular strain assessment in cardiac amyloidosis.
Retrospectively analyzed 32 patients with cardiac amyloidosis and 32 age-, sex-, rhythm-, and ejection fraction–matched controls.
Measured right ventricular (RV) free-wall strain using an investigational continuous biventricular contour from the basal RV free wall to the basal lateral left ventricular wall, comparing it with conventional RV strain.
Assessed reproducibility in a subset of 20 patients using intraclass correlation coefficients (ICC) and Bland–Altman analysis.
Investigational RV free-wall strain was significantly reduced in cardiac amyloidosis compared with controls (−15.3 ± 4.1% vs. −21.2 ± 5.4%, p < 0.001).
Investigational biventricular tracking yielded more negative RV strain values than conventional strain in amyloidosis (−15.3 ± 4.1% vs. −13.8 ± 4.8%, p = 0.003) and controls (−21.2 ± 5.4% vs. −17.4 ± 5.8%, p < 0.001), with a mean bias of −2.64 percentage points.
Inter- and intra-observer reproducibility was excellent (ICC 0.976 and 0.985, respectively), and investigational biventricular strain correlated strongly with LV global longitudinal strain overall (r = 0.84, p < 0.001).

Study Design

Type

Case-Control (n=64)

Structured PICO

Does an investigational biventricular tracking approach provide feasible and reproducible assessment of right ventricular strain compared to conventional methods in patients with cardiac amyloidosis?

Population

32 patients with cardiac amyloidosis and 32 matched controls evaluated retrospectively for right ventricular strain.

Exposure

Investigational biventricular tracking approach for right ventricular (RV) strain assessment based on a continuous biventricular tracking pathway within the apical four-chamber view.

Comparator

Conventional RV strain assessment.

Outcome

RV free-wall longitudinal strain.surrogate

Main Result

Absolute Event Rate: -15.3% vs -13.8%

p-value: p=0.003

A novel biventricular tracking approach is a feasible and highly reproducible method for assessing right ventricular longitudinal strain in cardiac amyloidosis, offering complementary information to conventional speckle-tracking.

Limitations

Anatomical specificity, clinical applicability, and prognostic value require further validation.

Cite This Study

Leitman et al. (2026) conducted a case-control in Cardiac amyloidosis (n=64). Investigational biventricular tracking approach vs. Conventional RV strain was evaluated on Global RV strain in patients with amyloidosis (p=0.003). The investigational biventricular tracking approach yielded more negative global RV strain values compared with conventional RV strain in patients with amyloidosis (-15.3% vs -13.8%, p=0.003).

synapsesocial.com/papers/6a9d1e6328139818eab211ec https://doi.org/10.3390/clinpract16090164

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September 6, 2026Clinics and PracticeOpen Access

An Alternative Biventricular Tracking Approach for Assessment of Right Ventricular Strain in Cardiac Amyloidosis

View Full Paper

Ask AI

Bookmark

Key result

Biventricular tracking yields ~1.5% more negative global RV strain than conventional assessment in amyloidosis.

P=0.003
n=64

Why the study?

Does an investigational biventricular tracking approach provide feasible and reproducible assessment of right ventricular strain compared to conventional methods in patients with cardiac amyloidosis?

Population

32 cardiac amyloidosis patients and 32 matched controls

Comparison

Investigational biventricular tracking approach vs conventional RV strain

Design

Retrospective case-control study

Authors

MLMarina LeitmanTel Aviv University VTVladimir TyomkinAssaf Harofeh Medical Center SFShmuel FuchsNational Archives and Records Administration

Discussion

Member takes

Implication

Biventricular tracking may refine RV strain assessment in amyloidosis; hypothesis-generating and should not yet change practice.

Key Points

Evaluate the feasibility, regional patterns, and reproducibility of a continuous biventricular tracking approach for right ventricular strain assessment in cardiac amyloidosis.
Retrospectively analyzed 32 patients with cardiac amyloidosis and 32 age-, sex-, rhythm-, and ejection fraction–matched controls.
Measured right ventricular (RV) free-wall strain using an investigational continuous biventricular contour from the basal RV free wall to the basal lateral left ventricular wall, comparing it with conventional RV strain.
Assessed reproducibility in a subset of 20 patients using intraclass correlation coefficients (ICC) and Bland–Altman analysis.
Investigational RV free-wall strain was significantly reduced in cardiac amyloidosis compared with controls (−15.3 ± 4.1% vs. −21.2 ± 5.4%, p < 0.001).
Investigational biventricular tracking yielded more negative RV strain values than conventional strain in amyloidosis (−15.3 ± 4.1% vs. −13.8 ± 4.8%, p = 0.003) and controls (−21.2 ± 5.4% vs. −17.4 ± 5.8%, p < 0.001), with a mean bias of −2.64 percentage points.
Inter- and intra-observer reproducibility was excellent (ICC 0.976 and 0.985, respectively), and investigational biventricular strain correlated strongly with LV global longitudinal strain overall (r = 0.84, p < 0.001).

Study Design

Type

Case-Control (n=64)

Structured PICO

Does an investigational biventricular tracking approach provide feasible and reproducible assessment of right ventricular strain compared to conventional methods in patients with cardiac amyloidosis?

Population

32 patients with cardiac amyloidosis and 32 matched controls evaluated retrospectively for right ventricular strain.

Exposure

Investigational biventricular tracking approach for right ventricular (RV) strain assessment based on a continuous biventricular tracking pathway within the apical four-chamber view.

Comparator

Conventional RV strain assessment.

Outcome

RV free-wall longitudinal strain.surrogate

Main Result

Absolute Event Rate: -15.3% vs -13.8%

p-value: p=0.003

Limitations

Anatomical specificity, clinical applicability, and prognostic value require further validation.

Cite This Study

synapsesocial.com/papers/6a9d1e6328139818eab211ec https://doi.org/10.3390/clinpract16090164

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