Key result
Higher HbA1c linked to ~57% greater 1-year major cardiovascular events risk in young suspected STEMI patients.
Why the study?
Clinical profiles, cardiovascular risk factors, and variables independently associated with 1-year MACE in young patients aged 45 years or younger presenting with suspected STEMI were not well defined.
Observational (n=126)
No
Answers are grounded in this paper and cite their sources.
In young patients (≤45 years) presenting with suspected STEMI, elevated HbA1c, history of CAD, and lower LVEF are independent predictors of 1-year major adverse cardiovascular events.
OBJECTIVE: This study aimed to determine the demographic and clinical profiles, cardiovascular risk factors, and variables independently associated with major adverse cardiovascular events (MACE) during 1-year follow-up in young patients aged 45 years or younger who presented with suspected ST-segment elevation myocardial infarction (STEMI) and underwent emergency coronary angiography. METHOD: This retrospective, single-center, observational study included 126 young patients presenting with suspected STEMI who underwent primary coronary angiography and/or percutaneous coronary intervention at a high-volume tertiary cardiovascular center between January 2021 and April 2025. Patients were classified into two groups according to the occurrence of MACE during 1-year follow-up: the MACE group (n=28) and the non-MACE group (n=98). HbA1c levels were assessed based on a single measurement obtained during the index MI admission. Logistic regression analyses were performed to identify variables independently associated with MACE. RESULTS: The median age of the overall cohort was 40 years (38-42), and 7.9% of the patients were female. During follow-up, MACE occurred in 22.2% of the patients. The all-cause mortality rate was 4.0%. Multivariable logistic regression analysis demonstrated that higher HbA1c levels (aOR: 1.57; 95% CI: 1.10-2.24; P = 0.014), a history of CAD (aOR: 3.93; 95% CI: 1.15-13.37; P = 0.029), and lower LVEF (aOR: 0.94; 95% CI: 0.88-0.99; P = 0.029) were independently associated with MACE. Notably, among patients without previously known diabetes, HbA1c levels ≥6.5% were significantly associated with an increased risk of MACE. CONCLUSION: Young patients presenting with suspected STEMI who undergo emergency coronary angiography may have a notable risk of MACE during the first year of follow-up. A history of CAD, lower LVEF, and elevated HbA1c levels appear to be associated with adverse clinical outcomes.
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Kış et al. (2026) conducted an observational in Suspected ST-segment elevation myocardial infarction (STEMI) (n=126). Higher HbA1c levels was evaluated on Major adverse cardiovascular events (MACE) (aOR 1.57, 95% CI 1.10-2.24, p=0.014). In young patients with suspected STEMI, higher HbA1c levels were independently associated with an increased risk of 1-year major cardiovascular events.