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September 6, 2026Epilepsia OpenOpen Access

Auditory gamma‐band synchronization and attentional performance in juvenile myoclonic epilepsy

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Authors

RMRyo MitomaSTShunsuke TamuraYHYoji Hirano

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Overview

Case-control study uncovers reduced auditory gamma synchronization linked to attention deficits in juvenile myoclonic epilepsy, suggesting thalamocortical network dysfunction.

Key Points

  • To investigate 40- and 80-Hz auditory steady-state responses using magnetoencephalography and evaluate their relationship with cognitive performance in juvenile myoclonic epilepsy.
  • Conducted a cross-sectional case-control study with 16 patients with juvenile myoclonic epilepsy (JME) and 16 age- and sex-matched healthy controls.
  • Recorded 40- and 80-Hz auditory steady-state responses (ASSRs) with magnetoencephalography to measure evoked power and phase-locking factor in bilateral primary auditory cortices.
  • Evaluated cognitive function with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and analyzed associations using linear mixed-effects models and false discovery rate corrections.
  • Linear mixed-effects models showed lower evoked power and phase-locking factor in JME patients compared to healthy controls (both p < 0.001).
  • Among the five RBANS cognitive indices, only the Attention Index was significantly lower in the JME group (FDR-adjusted p = 0.02).
  • Within the JME cohort, the Attention Index was positively associated with both evoked power (B = 16.65, 95% CI: 5.81 to 27.49; FDR-adjusted p = 0.03) and phase-locking factor (B = 38.82, 95% CI: 13.82 to 63.83; FDR-adjusted p = 0.03).

Cite This Study

Mitoma et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1ee128139818eab220fahttps://doi.org/10.1002/epi4.70330
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic causal modeling of effective connectivity generating a reduced auditory deviance detection in juvenile myoclonic epilepsy.2026
  2. 2Enhanced response inhibition in patients with drug‐resistant juvenile myoclonic epilepsy: Event‐related potentials evidence of excitatory–inhibitory imbalance2025
  3. 3Neuronal imbalance of excitation and inhibition in schizophrenia: a scoping review of gamma‐band ASSR findings2022 · 66 citations
  4. 4The Many Faces of Juvenile Myoclonic Epilepsy2025
  5. 5Functional brain network organization during the 40-Hz auditory steady-state response in children with and without autism spectrum disorder2026