Key result
A higher triglyceride glucose index (highest vs lowest quartile) was independently associated with increased odds of subclinical left ventricular systolic dysfunction (OR 5.23) in type 2 diabetes.
Why the study?
The association of the triglyceride glucose index with subclinical left ventricular systolic dysfunction lacked comprehensive exploration in patients with type 2 diabetes mellitus.
Does a higher triglyceride glucose (TyG) index predict subclinical left ventricular systolic dysfunction in patients with type 2 diabetes mellitus?
Cross-Sectional (n=150)
No
Does a higher triglyceride glucose (TyG) index predict subclinical left ventricular systolic dysfunction in patients with type 2 diabetes mellitus?
Odds Ratio: 5.23 (95% CI 1.12–24.51)
p-value: p=0.036
The triglyceride glucose (TyG) index is independently associated with subclinical left ventricular systolic dysfunction in patients with type 2 diabetes and preserved ejection fraction, suggesting its potential as an early biomarker for diabetic cardiomyopathy.
TyG index may flag higher subclinical LV dysfunction risk in T2D; hypothesis-generating and should not yet change practice.
BACKGROUND: The triglyceride glucose (TyG) index has been considered a new biomarker for the diagnosis of angiocardiopathy and insulin resistance. However, the association of the TyG index with subclinical left ventricular (LV) systolic dysfunction still lacks comprehensive exploration. This study was carried out to examine this relationship in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 150 T2DM patients with preserved LV ejection fraction (LVEF ≥ 50%) from June 2021 to December 2021 were included in this study. The subclinical LV function was evaluated through global longitudinal strain (GLS), with the predefined GLS < 18% as the cutoff for subclinical LV systolic dysfunction. The TyG index calculation was obtained according to ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2), which was then stratified into quartiles (TyG index-Q). RESULTS: Analyses of clinical characteristics in the four TyG indexes-Q (Q1 (TyG index ≤ 8.89) n = 38, Q2 (8.89 < TyG index ≤ 9.44) n = 37, Q3 (9.44 < TyG index ≤ 9.83) n = 38, and Q4 (TyG index > 9.83) n = 37) were conducted. A negative correlation of the TyG index with GLS (r = -0.307, P < 0.001) was revealed according to correlation analysis. After gender and age were adjusted in multimodel logistic regression analysis, the higher TyG index (OR 6.86; 95% CI 2.44 to 19.30; P < 0.001, Q4 vs Q1) showed a significant association with GLS < 18%, which was still maintained after further adjustment for related clinical confounding factors (OR 5.23, 95% CI 1.12 to 24.51, p = 0.036, Q4 vs Q1). Receiver operator characteristic analysis indicated a diagnostic capacity of the TyG index for GLS < 18% (area under curve: 0.678; P < 0.001). CONCLUSIONS: A higher TyG index had a significant association with subclinical LV systolic dysfunction in T2DM patients with preserved ejection fraction, and the TyG index may have the potential to exert predictive value for myocardial damage.
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Chen et al. (2023) conducted a cross-sectional in Type 2 diabetes mellitus with preserved left ventricular ejection fraction (n=150). Triglyceride glucose (TyG) index vs. Lowest TyG index quartile (Q1) was evaluated on Subclinical left ventricular systolic dysfunction (GLS < 18%) (OR 5.23, 95% CI 1.12-24.51, p=0.036). A higher triglyceride glucose index (highest vs lowest quartile) was independently associated with increased odds of subclinical left ventricular systolic dysfunction (OR 5.23) in type 2 diabetes.
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