Key result
A 5-day cottonseed oil-rich diet reduced fasting and postprandial ANGPTL3, -4, and -8 responses compared to an olive oil-rich diet in 15 male participants.
Why the study?
It is not known how cottonseed oil differentially affects postprandial responses of ANGPTL3, -4, and -8 in humans.
RCT (n=15)
Random order
Angiopoietin-like proteins (ANGPTL) 3, -4 and -8 regulate lipid metabolism by altering lipoprotein lipase activity, but it is not known how cottonseed oil (CSO) differentially affects postprandial responses of ANGPTL’s in humans. We compared the effect of a diet rich in either CSO or olive oil (OO) on fasting and postprandial ANGPTL’s. Fifteen males completed two feeding trials in random order: 1) a CSO-rich diet and 2) an OO-rich diet with fasting and postprandial blood samples collected pre-diet at visit 1 (v1) followed by a 5-day feeding trial and a post-diet visit (v2) identical to v1 and a 2–4-week washout period. Fasting ANGPTL4 and ANGPTL8 decreased from v1 to v2 after the CSO diet and increased with the OO diet. Postprandial ANGPTL3, -4, and -8 were lower following the CSO meal. The lipid-lowering effects of CSO may be mediated by reduced fasting and postprandial ANGPTL3, -4 and -8 responses.
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Kaviani et al. (2021) reported an RCT. Cottonseed oil-rich diet vs. Olive oil-rich diet was evaluated on Fasting and postprandial ANGPTL3, -4, and -8 levels. A 5-day cottonseed oil-rich diet reduced fasting and postprandial ANGPTL3, -4, and -8 responses compared to an olive oil-rich diet in 15 male participants.
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