A 7-day high-PUFA diet reduces angiopoietin-like protein 3 and 8 responses and postprandial triglyceride levels in healthy females but not males: a randomized control trial

Figures

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  Fig. 1. Plasma TG response to SFA-rich meals before and after the PUFA diet. Changes in plasma TG are presented in PUFA-diet female (a) (n = 8) and male (b) (n = 8) subjects, and control diet female (c) (n = 5) and male (D) (n = 5) subjects before (dashed line) and after (solid line) the diets. In PUFA-diet females only, plasma TG concentrations were significantly lower at 2, 4, and 6 h after the 7-day diet. These differences were not significant in PUFA males or either sexes in the control group; * indicates a significant decrease compared to pre-diet levels in females (p < 0.05)

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  Fig. 2. Plasma TG Area Under the Curve (AUC). Changes from fasting through 8 h post meals were assessed using AUC in females and males on PUFA-rich and control diets. The 8-h AUC indicated that the female PUFA-diet group reduced total TG response whereas the other 3 groups did not; * indicates a significant decrease compared to pre-diet levels in females (p < 0.05)

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  Fig. 3. Plasma ANGPTL3 response to SFA-rich meals before and after the PUFA diet. Changes in plasma ANGPTL3 are presented in PUFA-diet female (a) (n = 8) and male (b) (n = 8) subjects, and control diet female (c) (n = 5) and male (d) (n = 5) subjects before (dashed line) and after (solid line) the diets. In PUFA-diet females only, fasting ANGPTL3 values decreased from pre- to post-diet visit (p < 0.01), but not in PUFA males. There was no significant change seen from pre- to post-diet visit in either sexes in the control group; * indicates a significant decrease compared to pre-diet levels in females (p < 0.05)

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  Fig. 4. Postprandial ANGPTL3 Area Under the Curve (AUC). Changes from fasting through 8 h post meals were assessed using AUC in females and males on PUFA-rich and control diets. The 8-h AUC indicated that the female PUFA-diet group reduced total ANGPTL3 response whereas the other 3 groups did not; * indicates a significant decrease compared to pre-diet levels in females (p < 0.05)

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  Fig. 5. Plasma ANGPTL8 response to SFA-rich meals before and after the PUFA diet. Changes in plasma ANGPTL8 are presented in PUFA-diet female (a) (n = 8) and male (b) (n = 8) subjects, and control diet female (c) (n = 5) and male (d) (n = 5) subjects before (dashed line) and after (solid line) the diets. In PUFA-diet females only, fasting ANGPTL8 values decreased from pre- to post-diet visit (p < 0.05), but not in PUFA males. There was no significant change seen from pre- to post-diet visit in either sexes in the control group; * indicates a significant decrease compared to pre-diet levels in females (p < 0.05)

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  Fig. 6. Postprandial ANGPTL8 Area Under the Curve (AUC). Changes from fasting through 8 h post meals were assessed using AUC in females and males on PUFA-rich and control diets. The 8-h AUC indicated that the female PUFA-diet group reduced total ANGPTL8 response whereas the other 3 groups did not; * indicates a significant decrease compared to pre-diet levels in females (p < 0.05)

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  Fig. 7. Plasma ANGPTL4 response to SFA-rich meals before and after the PUFA diet. Changes in plasma ANGPTL4 are presented in PUFA-diet female (a) (n = 8) and male (b) (n = 8) subjects, and control diet female (c) (n = 5) and male (d) (n = 5) subjects before (dashed line) and after (solid line) the diets. There were no significant changes in ANGPTL4 from pre- to post-diet visit in either sexes or in either diet group

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  Fig. 8. Postprandial ANGPTL4 Area Under the Curve (AUC). Changes from fasting through 8 h post meals were assessed using AUC in females and males on PUFA-rich and control diets. There were no differences in 8-h AUC between diets among any of the four groups