Key result
A test meal with a high n-3 PUFA ratio did not acutely influence postprandial lipid, glucose, inflammatory, or endothelial responses compared to a low n-3 meal, though the low n-3 meal accentuated differences between hypertriglyceridemic and healthy subjects.
Why the study?
Does a high n-3 PUFA ratio meal improve postprandial metabolism compared to a low n-3 PUFA ratio meal in hypertriacylglycerolemia patients and healthy controls?
RCT (n=16)
Randomized
No
Does a high n-3 PUFA ratio meal improve postprandial metabolism compared to a low n-3 PUFA ratio meal in hypertriacylglycerolemia patients and healthy controls?
The n-6/n-3 PUFA ratio of a single meal does not acutely influence postprandial metabolism, inflammatory response, or endothelial function, though underlying hypertriglyceridemia drives worse postprandial responses.
Answers are grounded in this paper and cite their sources.
No acute postprandial benefit from high n-3 PUFA meals; challenges assumptions of rapid dietary fat quality effects.
BACKGROUND: Atherosclerosis is a postprandial phenomenon. The balanced n-6/n-3 PUFA ratio contributing to the prevention of atherosclerosis has been well shown, but the effect of the ratio on postprandial metabolism has not been fully investigated. The aim of this study was to investigate the effects of the n-6/n-3 PUFAs ratio on postprandial metabolism in hypertriacylglycerolemia patients, comparing them to healthy controls. METHODS: Test meals with 0.97 (high n-3) and 8.80 (low n-3) n-6/n-3 PUFAs ratio were administered in a randomized crossover design to 8 healthy and 8 hypertriacylglycerolemia subjects. Blood samples were collected for 8 hours after meals to measure triglyceride (TG), total cholesterol (TC), HDL, ApoA, ApoB, glucose, insulin, inflammatory makers including tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), endothelial function including nitric oxide (NO) and endothelin-1 (ET-1). RESULTS: According to repeated-measures ANOVA, the postprandial response of lipid, glucose, insulin, inflammation and endothelial function were not significantly different between meals. The postprandial TG and NO response were significantly different between healthy control (HC) and hypertriglyceridemia group (HTG) after both meals (P < 0.01). After both meals maximal change and iAUC for TG was all higher in HTG group than HC group, the difference was significant after low n-3 meal but not after high n-3 meal. The concentration of glucose, insulin, IL-6, TNFα and ET-1 at each time point was higher and NO was lower in HTG group, but the maximal change and iAUC had no significant difference except for iAUC of insulin, IL-6 and diAUC of NO after low n-3 meal. CONCLUSIONS: The ratio of n-6 and n-3 maybe do not acutely influence the postprandial metabolism, inflammatory response and endothelial function, but the low n-3 meal can strengthen the difference between HTG and HC group.
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Song et al. (2013) conducted an RCT in Hypertriacylglycerolemia (n=16). High n-3 test meal (n-6/n-3 ratio 0.97) vs. Low n-3 test meal (n-6/n-3 ratio 8.80) was evaluated on Postprandial triglyceride response (p=>0.05). A test meal with a high n-3 PUFA ratio did not acutely influence postprandial lipid, glucose, inflammatory, or endothelial responses compared to a low n-3 meal, though the low n-3 meal accentuated differences between hypertriglyceridemic and healthy subjects.
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