Key result
Intake of a meal rich in saturated fatty acids delayed the postprandial triglyceride peak to 4 hours compared to 2 hours for a polyunsaturated fat meal in subjects with and without familial hypercholesterolaemia, with no significant difference in total AUC.
Why the study?
Does a high-fat meal rich in SFA compared with PUFA alter the postprandial response of TAG and lipid sub-classes in subjects with and without familial hypercholesterolaemia?
RCT (n=27)
Double-blind
randomised
No
Does a high-fat meal rich in SFA compared with PUFA alter the postprandial response of TAG and lipid sub-classes in subjects with and without familial hypercholesterolaemia?
p-value: p=0.25 ≤ P ≤ 0.72
SFA and PUFA intake result in different timing of postprandial TAG peaks, but no significant difference in overall TAG levels between meals or between FH and control subjects.
SFA delays postprandial TAG peak versus PUFA in FH and controls alike; extends evidence on fat quality effects on lipid timing without changing total exposure.
Postprandial hypertriacylglycerolaemia is associated with an increased risk of developing CVD. How fat quality influences postprandial lipid response is scarcely explored in subjects with familial hypercholesterolaemia (FH). The aim of this study was to investigate the postprandial response of TAG and lipid sub-classes after consumption of high-fat meals with different fat quality in subjects with FH compared with normolipidaemic controls. A randomised controlled double-blind cross-over study with two meals and two groups was performed. A total of thirteen hypercholesterolaemic subjects with FH who discontinued lipid-lowering treatment 4 weeks before and during the study, and fourteen normolipidaemic controls, were included. Subjects were aged 18-30 years and had a BMI of 18·5-30·0 kg/m2. Each meal consisted of a muffin containing 60 g (70 E%) of fat, either mainly SFA (40 E%) or PUFA (40 E%), eaten in a random order with a wash-out period of 3-5 weeks between the meals. Blood samples were collected at baseline (fasting) and 2, 4 and 6 h after intake of the meals. In both FH and control subjects, the level of TAG and the largest VLDL sub-classes peaked at 2 h after intake of PUFA and at 4 h after intake of SFA. No significant differences were found in TAG levels between meals or between groups (0·25≤P≤0·72). The distinct TAG peaks may reflect differences in the postprandial lipid metabolism after intake of fatty acids with different chain lengths and degrees of saturation. The clinical impact of these findings remains to be determined.
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Øyri et al. (2018) conducted an RCT in Familial hypercholesterolaemia (n=27). SFA-rich meal vs. PUFA-rich meal was evaluated on Postprandial response of TAG (AUC and iAUC) (p=0.25 ≤ P ≤ 0.72). Intake of a meal rich in saturated fatty acids delayed the postprandial triglyceride peak to 4 hours compared to 2 hours for a polyunsaturated fat meal in subjects with and without familial hypercholesterolaemia, with no significant difference in total AUC.
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