Key result
A high-saturated fatty acid mixed meal decreased circulating ANGPTL4 concentrations from 5.2 ng/mL fasting to 4.0 ng/mL at 4 hours postprandial (P < .001).
Why the study?
Does a high-saturated fatty acid mixed meal affect plasma ANGPTL4 concentrations and skeletal muscle lipid metabolism in overweight and obese individuals?
Population
73 overweight and obese humans, and a subset of 10 obese insulin-resistant participants
Comparison
High-saturated fatty acid mixed meal; dietary… vs Fasting conditions; high-monounsaturated fat meal
Design
Other
Follow-up
4 hours postprandial
Authors
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Postprandial ANGPTL4 decline after high-SFA meals shows no link to muscle LPL activity; leaves open whether fat quality modulates short-term skeletal muscle lipid handling.
Observational (n=83)
No
Does a high-saturated fatty acid mixed meal affect plasma ANGPTL4 concentrations and skeletal muscle lipid metabolism in overweight and obese individuals?
Absolute Event Rate: 4% vs 5.2%
p-value: p=<.001
A high-saturated fat meal decreases circulating ANGPTL4 concentrations and induces its secretion from skeletal muscle in overweight and obese individuals, though this does not correlate with short-term skeletal muscle LPL activity.
Kolk et al. (2016) conducted an observational in Overweight and obese prediabetes (n=83). High-saturated fatty acid (SFA) mixed meal vs. Fasting conditions was evaluated on Plasma ANGPTL4 concentrations (p=<.001). A high-saturated fatty acid mixed meal decreased circulating ANGPTL4 concentrations from 5.2 ng/mL fasting to 4.0 ng/mL at 4 hours postprandial (P < .001).
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