Key result
Decreasing intracellular pH from 7.2 to 6.4 increased cardiac K+ATP channel activity by reducing its sensitivity to ATP, while reducing single channel conductance from 89.0 to 77.7 pS.
Intracellular acidification modulates cardiac K+ATP channels by decreasing their sensitivity to ATP and reducing their permeability.
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May modulate ischemic K+ATP responses in animal models; leaves open translation to human cardioprotection.
Koyano et al. (1993) studied this question. Decreased intracellular pH vs. Baseline or higher intracellular pH was evaluated on K+ATP channel activity and single channel conductance. Decreasing intracellular pH from 7.2 to 6.4 increased cardiac K+ATP channel activity by reducing its sensitivity to ATP, while reducing single channel conductance from 89.0 to 77.7 pS.
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