Key result
Lipoprotein(a) levels remained constant during cardiopulmonary bypass but decreased from a baseline geometric mean of 115 mg/L to 62 mg/L at the third post-operative day, mimicking total cholesterol.
Why the study?
How do serum levels of lipoprotein(a), cholesterol, and triglycerides change during and after coronary artery bypass grafting?
Observational (n=20)
How do serum levels of lipoprotein(a), cholesterol, and triglycerides change during and after coronary artery bypass grafting?
Lipoprotein(a) levels remain stable during cardiopulmonary bypass but decrease post-operatively, mirroring changes in total cholesterol.
Post-CABG Lp(a) decline should not yet alter monitoring or risk models; leaves open its prognostic value versus cholesterol changes.
The lipoprotein(a) (Lp(a)) time course during and after coronary artery bypass grafting was examined in 20 caucasoid patients, in relation to the time courses of serum cholesterol and serum triglycerides. Samples were taken at eight different time points. Baseline geometric means (SD) for Lp(a), cholesterol and triglycerides were 115 (336) mg/L, 5.73 (1.10) mmol/L and 1.73 (1.21) mmol/L, respectively. Up to 10 min after cardiopulmonary bypass (CPB) and after correction for haemodilution, no observable effect of CPB on serum concentrations of Lp(a) could be demonstrated, whereas serum concentrations of total cholesterol and triglycerides showed a progressive and significant decline. Ten minutes after stopping CPB geometric means for cholesterol and triglyceride were 3.90 (0.82) and 0.90 (0.58) mmol/L, respectively. At the third post-operative day geometric Lp(a) and cholesterol means decreased to 62(90) mg/L and 2.97 (0.84) mmol/L, respectively, while triglycerides went up. It is concluded that Lp(a) levels remain constant during CPB, but mimic total cholesterol changes in the post-CABG period.
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Cobbaert et al. (1998) conducted an observational in Coronary artery bypass grafting (n=20). Cardiopulmonary bypass during coronary artery bypass grafting vs. Baseline levels was evaluated on Lipoprotein(a) time course. Lipoprotein(a) levels remained constant during cardiopulmonary bypass but decreased from a baseline geometric mean of 115 mg/L to 62 mg/L at the third post-operative day, mimicking total cholesterol.
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