Key result
Antidepressant treatment, particularly SSRIs, was associated with significantly lower suicide attempt rates compared to no antidepressant treatment among adult veterans with depression.
Why the study?
Does antidepressant therapy reduce suicide attempts in adult veterans with depression?
Population
226,866 veterans in the US Veterans Administration health care system diagnosed with depression in 2003 or…
Comparison
Antidepressant therapy vs No antidepressant therapy, and within-patient…
Design
Cohort
Follow-up
at least 6 months
Authors
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Hypothesis-generating for lower suicide risk with antidepressants in veterans; prospective RCTs needed before clinical adoption.
Cohort (n=226,866)
Yes
Does antidepressant therapy reduce suicide attempts in adult veterans with depression?
In adult veterans with depression, antidepressant treatment, particularly with SSRIs, is associated with a reduced risk of suicide attempts, challenging concerns about increased suicidality in adults.
Gibbons et al. (2007) conducted a cohort in Depression (n=226,866). Antidepressants (SSRIs, non-SSRIs, tricyclics) vs. No antidepressant was evaluated on Suicide attempts. Antidepressant treatment, particularly SSRIs, was associated with significantly lower suicide attempt rates compared to no antidepressant treatment among adult veterans with depression.
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