Why the study?
The study was conducted to evaluate the relationship between body fat index and pulmonary health.
Does increased body fat mass/percentage reduce lung function and increase the risk of COPD in the general population?
Cross-Sectional (n=4,127)
Does increased body fat mass/percentage reduce lung function and increase the risk of COPD in the general population?
Odds Ratio: 1.936
p-value: p=<0.001
Increased body fat, particularly in the legs, is causally associated with reduced lung function and an increased risk of COPD.
Objective: To evaluate the relationship between body fat index and pulmonary health. Methods: In the multiethnic population-based cross-sectional study, a multivariable linear regression model was adapted to assess the association of fat mass/percentage with forced expiratory volume in 1 second (FEV 1 )/forced vital capacity (FVC). The Mendelian Randomization (MR) method was used to assess the causal associations of fat mass/percentage in specific body parts with FEV 1 and COPD risk. Sensitivity analysis of MR was performed to assess the robustness of estimates. Results: In the cross-sectional analysis, a non-linear relationship was observed between fat mass and FEV 1 without adjustment. After multivariate adjustment, the negative associations of fat mass/percentage with FEV 1 /FVC were found. In the MR study, genetically determined fat presented a negative causal effect on FEV 1 (e.g., estimate = − 0.170, P < 0.001 for left leg fat mass). The causal associations of genetically determined body fat with clinical diagnosis COPD were also determined (e.g., OR = 1.936, P < 0.001 per 1.9 kilograms increase in left leg fat mass). Conclusion: We present strong evidence on the causal relationship between body fat mass/percentage and both the deterioration of lung function and the increased risk of COPD. Additional efforts are required to mitigate the negative effects of body fat.
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Wang et al. (2025) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) and impaired lung function (n=4,127). Body fat mass and percentage vs. Lower body fat mass and percentage was evaluated on Clinical diagnosis of COPD (OR 1.936, p=<0.001).
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