Primary biopsies from 52 patients with cancer of the larynx were examined by two pathologists working independently. The malignancy of each case was graded twice with an interval of 1--1 1/2 month according to a histological scoring system elaborated by Jacobsson. The reproducibility of the system was found poor for individual prognostic purposes and no connection between histological grade and clinical course was demonstrated.
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Helweg‐Larsen et al. (1978) studied this question.
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