What question did this study set out to answer?

To assess the prognostic significance of tumor cell proliferative activity using the Ki-67 monoclonal antibody in patients with soft tissue sarcoma.

April 15, 1989Cancer

Prognostic significance of Ki-67 reactivity in soft tissue sarcomas

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Authors

TUTakafumi UedaThe University of Osaka KAKatsuyuki AozasaThe University of Osaka MTMasahiko TsujimotoKyoto University

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Implication

Cohort study demonstrates that high Ki-67 proliferative activity predicts unfavorable prognosis in soft tissue sarcoma, suggesting its value as a histologic grading marker.

Key Points

To assess the prognostic significance of tumor cell proliferative activity using the Ki-67 monoclonal antibody in patients with soft tissue sarcoma.
Evaluated proliferative activity in 34 soft tissue sarcoma cases using avidin-biotin complex immunohistochemistry with monoclonal antibody Ki-67.
Calculated the Ki-67 index by counting positive tumor cells per 10 high-power fields (HPF), establishing a cutoff of 50/10 HPF to separate low- and high-index groups.
Correlated the Ki-67 index with mitotic count, cellularity, histologic grade, and patient prognosis.
Ki-67 positivity was detected in 59% of cases (20/34; mean 57.2/10 HPF) and correlated with mitotic count (r = 0.428, P < 0.02), cellularity (r = 0.447, P < 0.01), and histologic grade (r = 0.473, P < 0.01).
Patients in the low Ki-67 index group (<50/10 HPF) demonstrated significantly more favorable survival compared to the high index group (>50/10 HPF; P < 0.005).
Three patients with low mitotic counts who experienced poor clinical outcomes were reclassified into the Ki-67 high index group (142–382/10 HPF).

Cite This Study

Ueda et al. (1989) studied this question.

synapsesocial.com/papers/6a9d51fc3685bbe8d2fce08b https://doi.org/10.1002/1097-0142(19890415)63:8<1607::aid-cncr2820630827>3.0.co;2-1

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Implication

Cohort study demonstrates that high Ki-67 proliferative activity predicts unfavorable prognosis in soft tissue sarcoma, suggesting its value as a histologic grading marker.

Prognostic significance of Ki-67 reactivity in soft tissue sarcomas

Discussion

Member takes

Implication

Key Points

Cite This Study

Prognostic significance of Ki-67 reactivity in soft tissue sarcomas

Discussion

Member takes

Implication

Key Points

Cite This Study

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