Key result
Immune-mediated induction of procoagulant activity is central to the initiation of fibrin formation in a variety of inflammatory diseases.
Discusses the role of immune-mediated procoagulant activity in various inflammatory diseases.
Alerts clinicians to immune contributions in inflammatory thrombosis; leaves open targeted interventions for prospective testing.
It is now apparent that immune mediated induction of monocyte/macrophage and vascular endothelial cell procoagulant activity is central to initiation of the fibrin formation that is a hall- mark of many inflammatory lesions.'9As such, a role for procoagulant activity has been cited in a variety of diseases including endotoxaemia,'°1' murine and human glomerular nephritis,'2 allograft rejection,' fulminant murine and human viral hepatitis,45 vasculitis of immune
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Wakefield et al. (1990) conducted a review in Inflammatory lesions. Procoagulant activity was evaluated. Immune-mediated induction of procoagulant activity is central to the initiation of fibrin formation in a variety of inflammatory diseases.
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