Key result
Secondary cardiac neoplasms were found in 14% of autopsies, with a significantly increased prevalence during the later period (1966-1977) related to attempted curative surgical and/or radiation therapy.
Why the study?
Does attempted curative surgical and/or radiation therapy increase the prevalence of secondary cardiac neoplasms in patients with metastatic malignancies?
Population
1303 autopsies with metastatic non-reticuloendothelial and non-central nervous system malignancies
Comparison
Attempted curative surgical and/or radiation… vs Earlier time period / no such therapy
Design
Cohort
Follow-up
25-year review period
Authors
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Rise in secondary cardiac neoplasms may associate with curative therapies; hypothesis-generating for surveillance in metastatic malignancy.
Observational (n=1,303)
Does attempted curative surgical and/or radiation therapy increase the prevalence of secondary cardiac neoplasms in patients with metastatic malignancies?
The prevalence of secondary cardiac neoplasms in patients with metastatic malignancies increased over time, likely related to attempted curative surgical and/or radiation therapy.
Lockwood et al. (1980) conducted an observational in Metastatic non-reticuloendothelial and non-central nervous system malignancies (n=1,303). Attempted curative surgical and/or radiation therapy (and later time period 1966-1977) vs. Earlier time period / no such therapy was evaluated on Secondary cardiac neoplasms. Secondary cardiac neoplasms were found in 14% of autopsies, with a significantly increased prevalence during the later period (1966-1977) related to attempted curative surgical and/or radiation therapy.
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