STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression

Signal transducer and activator of transcription-3 (STAT3) is a dimerizing transcription factor and oncogene involved in cytokine growth signaling and cell survival pathways.[1][1] While inactivating STAT3 mutations have been identified in hyper-IgE syndrome,[2][2] activating mutations are seen in