Key result
Single high dose and repeated low dose of niacin attenuated brain injury and improved neurological outcome after cardiac arrest in rats.
Why the study?
Does niacin attenuate brain injury and improve neurological outcome after cardiac arrest in rats?
Does niacin attenuate brain injury and improve neurological outcome after cardiac arrest in rats?
In a rat model of cardiac arrest, high-dose or repeated low-dose niacin attenuated brain injury and improved neurological outcomes, potentially via suppression of the MAPK pathway.
Niacin shows neuroprotective effects in rat cardiac arrest; hypothesis-generating and leaves open human translation.
No takes yet. Share an insight, caveat, or question.
Kwon et al. (2013) studied Brain injury after cardiac arrest (n=77). Niacin vs. Vehicle was evaluated on Neurologic deficit scales at 24 hours, 72 hours, and 7 days postreturn of spontaneous circulation. Single high dose and repeated low dose of niacin attenuated brain injury and improved neurological outcome after cardiac arrest in rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: