Key result
Total intravenous anesthesia with propofol in thyrotoxicosis patients caused a significant 34.6% decrease in mean arterial pressure and a 14.8% decrease in cardiac output immediately after induction, which stabilized during subsequent surgical stages.
Why the study?
Does total intravenous anesthesia with propofol affect central hemodynamics and oxygen delivery in patients with thyrotoxicosis syndrome undergoing thyroidectomy?
Observational (n=41)
No
Does total intravenous anesthesia with propofol affect central hemodynamics and oxygen delivery in patients with thyrotoxicosis syndrome undergoing thyroidectomy?
Effect estimate: 34.61% decrease
Absolute Event Rate: 68.17% vs 104.25%
p-value: p=<0.01
Total intravenous anesthesia with propofol in thyrotoxicosis patients causes a transient, manageable depression of hemodynamics and oxygen delivery during induction, which stabilizes during surgery without delayed negative effects.
Propofol TIVA may cause transient hemodynamic depression in thyrotoxicosis; leaves open optimal agent selection pending randomized trials.
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Тарасенко et al. (2018) conducted an observational in Thyrotoxicosis syndrome (n=41). Total intravenous anesthesia (TIVA) with propofol vs. Baseline (pre-induction) was evaluated on Mean arterial pressure (MBP) at stage 3 (after induction) compared to stage 2 (pre-induction) (34.61% decrease, p=<0.01). Total intravenous anesthesia with propofol in thyrotoxicosis patients caused a significant 34.6% decrease in mean arterial pressure and a 14.8% decrease in cardiac output immediately after induction, which stabilized during subsequent surgical stages.
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